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Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate

Dan Lundberg (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; G. Lafitte ; H. Ljusberg-Wahren ; P. Lennernas ; K. Thuresson
Journal of Dispersion Science and Technology (0193-2691). Vol. 30 (2009), 6, p. 920-928.
[Artikel, refereegranskad vetenskaplig]

The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.

Nyckelord: Bioavailability, cationic amphiphile, microemulsion, mucin, self-emulsifying drug-delivery system, drug-delivery systems, nonionic surfactant, light-scattering, phase-behavior, mixed micelles, in-vitro, gastrointestinal mucus, counterion binding, ussing chamber, diffusion



Denna post skapades 2010-03-01.
CPL Pubid: 116773

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)

Ämnesområden

Fysikalisk kemi

Chalmers infrastruktur