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Systems biology of lipid metabolism: From yeast to human

Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Febs Letters (0014-5793). Vol. 583 (2009), 24, p. 3905-3913.
[Artikel, refereegranskad vetenskaplig]

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Nyckelord: Systems biology, Lipid metabolism, Yeast, Metabolic model, saccharomyces-cerevisiae, transcription factors, phospholipid, biosynthesis, glucose repression, networks reveals, fatty-acid, reconstruction, proteins, models, genes


146th Nobel Symposium on Systems Biology Drobak, NORWAY, JUN 25-27, 2009



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Denna post skapades 2010-03-01. Senast ändrad 2014-11-05.
CPL Pubid: 116668

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Livsvetenskaper
Biokemisk och bioteknisk processteknik

Chalmers infrastruktur