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ncRNA-mediated bistability in the synthesis of hundreds of distinct mRNAs and proteins

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Biologisk fysik)
Physica A: Statistical Mechanics and its Applications (0378-4371). Vol. 389 (2010), 4, p. 887-890.
[Artikel, refereegranskad vetenskaplig]

The kinetics of gene expression can be bistable due to the feedback between the mRNA and protein formation. In eukaryotic cells, the interplay between mRNAs and proteins can be influenced by non-coding RNAs. Some of these RNAs, e.g., microRNAs, may target hundreds of distinct mRNAs. The model presented here shows how a non-coding RNA can be used as a mediator in order to involve numerous mRNAs and proteins into a bistable network.

Nyckelord: Subcellular processes, Gene transcription, mRNA and ncRNA synthesis, mRNA translation, mRNA, ncRNA and protein degradation, ncRNA-mRNA association,Mean-field kinetic equations, Bifurcations

Denna post skapades 2010-02-25. Senast ändrad 2017-08-18.
CPL Pubid: 115014


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Institutioner (Chalmers)

Institutionen för teknisk fysik, Biologisk fysik (2007-2015)


Biologisk fysik

Chalmers infrastruktur