CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Model of gene transcription including the return of a RNA polymerase to the beginning of a transcriptional cycle

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Physical Review E (1539-3755). Vol. 80 (2009), 5, p. art no 051925 .
[Artikel, refereegranskad vetenskaplig]

The gene transcription occurs via the RNA polymerase (RNAP) recruitment on the DNA promoter sequence, formation of a locally open DNA chain, promoter escape, steps of the RNA synthesis, and RNA and RNAP release after reading the final DNA base. Just after the end of the RNA synthesis, RNAP surrounds the closed DNA chain and may diffuse along DNA, desorb, or reach the promoter and start the RNA-synthesis cycle again. We present a generic kinetic model taking the latter steps into account and show analytically and by Monte Carlo simulations that it predicts transcriptional bursts even in the absence of explicit regulation of the transcription by master proteins.

Nyckelord: DNA, genetics, kinetic theory, macromolecules, molecular biophysics, Monte Carlo methods, proteins, regulatory networks, ii transcription, coding-rna, dna, expression, protein, initiation, elongation, diffusion, stochasticity



Denna post skapades 2010-02-25. Senast ändrad 2014-03-24.
CPL Pubid: 114904

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för teknisk fysik, Kemisk fysik (1900-2015)

Ämnesområden

Plasmafysik med fusion
Matematisk fysik

Chalmers infrastruktur