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Protein adsorption and desorption on lipid bilayers

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik) ; Bengt Kasemo (Institutionen för teknisk fysik, Kemisk fysik)
Biophysical Chemistry (0301-4622). Vol. 146 (2010), 2-3, p. 60-64.
[Artikel, refereegranskad vetenskaplig]

The protein surface usually exhibits one or a few charged spots. If a lipid bilayer contains a significant amount of lipids with oppositely charged head groups, protein adsorption on a bilayer may be energetically favourable due to the protein-lipid electrostatic interaction. The specifics of this case are that the lipids are highly mobile and the protein adsorption is accompanied by the redistribution of lipids between the areas covered and not covered by protein. We present a kinetic model illustrating that this effect is especially interesting if the fraction of the surface covered by charged lipids is relatively low. In this situation, with increasing protein coverage, the protein desorption rate constant rapidly increases while the adsorption rate constant drops, so that there is critical fraction of the area covered by protein. Adsorption above this fraction is hindered both kinetically and thermodynamically.

Nyckelord: Proteins, Lipids, Adsorption and desorption kinetics, Lipid, redistribution, Electrostatic interactions, monte-carlo simulations, excluded surface-area, solid-surfaces, charged, macromolecules, phospholipid-bilayers, qcm-d, membranes, kinetics, electrostatics, aggregation

Denna post skapades 2010-02-24. Senast ändrad 2014-03-24.
CPL Pubid: 114608


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