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**Harvard**

Mancusi, D., Sihver, L., Niita, K., Li, Q., Sato, T., Iwase, H., Iwamoto, Y., Matsuda, N., Sakamoto, Y. och Nakashima, H. (2009) *Calculation of Energy-Deposition Distributions and Microdosimetric Estimation of the Biological Effect of a 9C Beam*.

** BibTeX **

@article{

Mancusi2009,

author={Mancusi, Davide and Sihver, Lembit and Niita, K. and Li, Q and Sato, T. and Iwase, H. and Iwamoto, Y. and Matsuda, N. and Sakamoto, Y. and Nakashima, H.},

title={Calculation of Energy-Deposition Distributions and Microdosimetric Estimation of the Biological Effect of a 9C Beam},

journal={Radiation and Environmental Biophysics},

issn={0301-634X},

volume={48},

issue={2},

pages={135-143},

abstract={Among the alternative beams being recently considered for external cancer radiotherapy, C-9 has received some attention because it is expected that its biological effectiveness could be boosted by the beta-delayed emission of two alpha particles and a proton that takes place at the ion-stopping site. Experiments have been performed to characterise this exotic beam physically and models have been developed to estimate quantitatively its biological effect. Here, the particle and heavy-ion transport code system (PHITS ) is used to calculate energy-deposition and linear energy transfer distributions for a C-9 beam in water and the results are compared with published data. Although PHITS fails to reproduce some of the features of the distributions, it suggests that the decay of C-9 contributes negligibly to the energy-deposition distributions, thus contradicting the previous interpretation of the measured data. We have also performed a microdosimetric calculation to estimate the biological effect of the decay, which was found to be negligible; previous microdosimetric Monte-Carlo calculations were found to be incorrect. An analytical argument, of geometrical nature, confirms this conclusion and gives a theoretical upper bound on the additional biological effectiveness of the decay. However, no explanation can be offered at present for the observed difference in the biological effectiveness between C-9 and C-12; the reproducibility of this surprising result will be verified in coming experiments. },

year={2009},

}

** RefWorks **

RT Journal Article

SR Print

ID 111285

A1 Mancusi, Davide

A1 Sihver, Lembit

A1 Niita, K.

A1 Li, Q

A1 Sato, T.

A1 Iwase, H.

A1 Iwamoto, Y.

A1 Matsuda, N.

A1 Sakamoto, Y.

A1 Nakashima, H.

T1 Calculation of Energy-Deposition Distributions and Microdosimetric Estimation of the Biological Effect of a 9C Beam

YR 2009

JF Radiation and Environmental Biophysics

SN 0301-634X

VO 48

IS 2

SP 135

OP 143

AB Among the alternative beams being recently considered for external cancer radiotherapy, C-9 has received some attention because it is expected that its biological effectiveness could be boosted by the beta-delayed emission of two alpha particles and a proton that takes place at the ion-stopping site. Experiments have been performed to characterise this exotic beam physically and models have been developed to estimate quantitatively its biological effect. Here, the particle and heavy-ion transport code system (PHITS ) is used to calculate energy-deposition and linear energy transfer distributions for a C-9 beam in water and the results are compared with published data. Although PHITS fails to reproduce some of the features of the distributions, it suggests that the decay of C-9 contributes negligibly to the energy-deposition distributions, thus contradicting the previous interpretation of the measured data. We have also performed a microdosimetric calculation to estimate the biological effect of the decay, which was found to be negligible; previous microdosimetric Monte-Carlo calculations were found to be incorrect. An analytical argument, of geometrical nature, confirms this conclusion and gives a theoretical upper bound on the additional biological effectiveness of the decay. However, no explanation can be offered at present for the observed difference in the biological effectiveness between C-9 and C-12; the reproducibility of this surprising result will be verified in coming experiments.

LA eng

OL 30