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Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process

N. Lalam ; C. Jacob ; Peter Jagers (Institutionen för matematiska vetenskaper, matematisk statistik)
Comptes Rendus Mathematique (1631073X ). Vol. 341 (2005), 10, p. 631-634.
[Artikel, refereegranskad vetenskaplig]

We propose a stochastic modelling of the PCR amplification process by a size-dependent branching process starting as a supercritical Bienaymé-Galton-Watson transient phase and then having a saturation near-critical size-dependent phase. This model based on the concept of saturation allows one to estimate the probability of replication of a DNA molecule at each cycle of a single PCR trajectory with a very good accuracy.



Denna post skapades 2010-01-22. Senast ändrad 2014-12-09.
CPL Pubid: 110303

 

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Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Matematisk statistik

Chalmers infrastruktur