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Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates

Y. Parajo ; J. Malina ; I. Meistermann ; G. J. Clarkson ; M. Pascu ; A. Rodger ; M. J. Hannon ; Per Lincoln (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Dalton Transactions (1477-9226). 25, p. 4868-4874. (2009)
[Artikel, refereegranskad vetenskaplig]

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

Nyckelord: linear dichroism spectroscopy, supramolecular cylinder, molecular, recognition, nucleic-acids, complexes, junction, nmr

Denna post skapades 2010-01-14. Senast ändrad 2016-08-22.
CPL Pubid: 107236


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)


Fysikalisk kemi

Chalmers infrastruktur