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Synthetic applications of cationic iron and cobalt carbonyl complexes

Karen M. Bromfield ; H. Graden ; N. Ljungdahl ; Nina Kann (Institutionen för kemi- och bioteknik, Organisk kemi)
Dalton Transactions (1477-9226). 26, p. 5051-5061. (2009)
[Artikel, refereegranskad vetenskaplig]

Metal carbonyl stabilized cationic species react with a wide range of nucleophiles under mild conditions, and have thus found many synthetic applications. In this Perspective, we describe the utility of iron carbonyl dienyl cations in solution and solid phase parallel synthesis, and in the development of a new synthetic route towards oseltamivir phosphate (Tamiflu). We also discuss the solid phase version of the Nicholas reaction, employing cobalt carbonyl stabilized propargylic cations, and giving access to substituted alkynes.

Nyckelord: pauson-khand reaction, solid-phase synthesis, neuraminidase inhibitor, oseltamivir, asymmetric catalytic complexation, dicobalt hexacarbonyl, complexes, sonogashira coupling reactions, potent antiinfluenza, activity, transition-metal-complexes, organic-synthesis, nicholas, reaction



Denna post skapades 2010-01-14. Senast ändrad 2010-06-14.
CPL Pubid: 107234

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Organisk kemi (2006-2014)

Ämnesområden

Kemi
Fysikalisk kemi
Organisk kemi

Chalmers infrastruktur