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DNA Duplex Length and Salt Concentration Dependence of Enthalpy-Entropy Compensation Parameters for DNA Melting

Evgeni B. Starikov (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Bengt Nordén (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Journal of Physical Chemistry B (1520-6106). Vol. 113 (2009), 33, p. 11375-11377.
[Artikel, refereegranskad vetenskaplig]

Systematical differential calorimetry experiments on DNA oligomers with different lengths, and placed in water solutions with various added salt concentrations may, in principle, unravel important information about the structure and dynamics of the DNA and their water-counterion surrounding. With this in mind, to reinterpret the most recent results of calorimetric experiments on DNA oligomers; of such a kind, the recent enthalpy-entropy compensation theory has been used. It is demonstrated that the application of the latter could enable direct estimation of thermodynamic parameters of the microphase transitions connected to the changes in DNA dynamical regimes versus the length of the biopolymers and the ionic strengths of their water solutions, and this calls for much more systematical experimental and theoretical studies in this field.

Nyckelord: translocation, spectrum, binding, plasmon

Denna post skapades 2010-01-14. Senast ändrad 2010-01-25.
CPL Pubid: 107227


Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)


Fysikalisk kemi

Chalmers infrastruktur