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Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets

Anna Viridén (SuMo Biomaterials ; Institutionen för kemi- och bioteknik, Farmaceutisk teknologi) ; Bengt Wittgren ; Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials)
European Journal of Pharmaceutical Sciences (0928-0987). Vol. 36 (2009), 2-3, p. 297-309.
[Artikel, refereegranskad vetenskaplig]

Four different HPMC batches were characterized to investigate properties related to crit. functionality for their use in hydrophilic matrix tablets. In this study, the HPMC batches were chem. characterized and correlated to the behavior of pure HPMC tablets. Parameters such as the mol. wt., viscosity, intrinsic viscosity and radius of gyration were kept in a rather limited range, which resulted in a weak correlation to polymer release and degree of swelling. The hydrophilic/hydrophobic character of the HPMC samples was elucidated by the degree of substitution and by the clouding behavior, where an increased hydrophilicity increased the tablet swelling. This phenomenon was interpreted in a refined model for water transport into HPMC tablets. A five times slower polymer release and a considerably larger degree of swelling were found for one batch of HPMC tablets compared to the others, although the characterized av. polymer parameters were in the same range. However, the conformation plot displayed a fraction with compact aggregates. In conclusion, the existence of aggregates in aq. soln. seems to perturb the functionality of HPMC tablets and it seems important to understand and characterize these aggregates to fully predict the polymer release and swelling of HPMC tablets.

Nyckelord: Cloud point, Dissolution, Hydrophilicity, Molecular weight, Particle size distribution, Pharmaceutical tablets, Radius of gyration, Swelling, Tensile strength, Viscosity (crit. polymer properties for polymer release and swelling of HPMC matrix tablets), Polymers Role: PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (crit. polymer properties for polymer release and swelling of HPMC matrix tablets), HPMC polymer swelling release hydrophilic matrix tablet



Denna post skapades 2010-01-12. Senast ändrad 2016-07-26.
CPL Pubid: 106436

 

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Institutioner (Chalmers)

SuMo Biomaterials
Institutionen för kemi- och bioteknik, Farmaceutisk teknologi (2005-2014)

Ämnesområden

Galenisk farmaci

Chalmers infrastruktur

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