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Influence of Substitution Pattern on Solution Behavior of Hydroxypropyl Methylcellulose

Anna Viridén (SuMo Biomaterials ; Institutionen för kemi- och bioteknik, Farmaceutisk teknologi) ; Bengt Wittgren ; Thomas Andersson ; Susanna Abrahmsen-Alami ; Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials)
Biomacromolecules (1525-7797). Vol. 10 (2009), 3, p. 522-529.
[Artikel, refereegranskad vetenskaplig]

Industrially produced hydroxypropyl Me cellulose (HPMC) is a chem. heterogeneous material, and it is thus difficult to predict parameters related to function on the basis of the polymer's av. chem. values. In this study, the soln. behavior of 7 HPMC batches was correlated to the mol. wt., degree of substitution, and substituent pattern. The initial onset of phase sepn., so-called clouding, generally followed an increased av. mol. wt. and degree of substitution. However, the slope of the clouding curve was affected by the substitution pattern, where the heterogeneously substituted batches had very shallow slopes. Further investigations showed that the appearance of a shallow slope of the clouding curve was a result of the formation of reversible polymer structures, formed as a result of the heterogeneous substituent pattern. These structures grew in size with temp. and concn. and resulted in an increase in the viscosity of the solns. at higher temps.

Nyckelord: Cloud point, Molecular weight distribution, Phase separation, Viscosity (substitution pattern effect on soln. behavior of hydroxypropyl Me cellulose), substitution soln behavior hydroxypropyl methyl cellulose

Denna post skapades 2010-01-12. Senast ändrad 2016-07-26.
CPL Pubid: 106435


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Institutioner (Chalmers)

SuMo Biomaterials
Institutionen för kemi- och bioteknik, Farmaceutisk teknologi (2005-2014)


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Investigation of the functionality related characteristics of hydroxypropyl methylcellulose for the release from matrix tablets