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From relative risk to absolute fracture risk calculation: the FRAX algorithm.

Eugene V McCloskey ; Helena Johansson ; Anders Odén (Institutionen för matematiska vetenskaper, matematisk statistik) ; John A Kanis
Current osteoporosis reports (1544-2241). Vol. 7 (2009), 3, p. 77-83.
[Artikel, refereegranskad vetenskaplig]

FRAX is a computer-based algorithm that provides models for the assessment of fracture probability in men and women (http://www.shef.ac.uk/FRAX). The approach uses easily obtained clinical risk factors to estimate 10-year fracture probability, with or without femoral neck bone mineral density (BMD), to enhance fracture risk prediction. It has been constructed using primary data from population-based cohorts around the world. The gradients of fracture risk have been validated in independent cohorts with a similar geographic distribution. The FRAX tool should not be considered as a gold standard, but rather as a platform technology on which to build as new validated risk indicators become available. Notwithstanding, the present models provide an aid to enhance patient assessment by the integration of clinical risk factors alone and/or in combination with BMD. This article describes the steps undertaken in the development of FRAX.

Nyckelord: Algorithms, Bone Density, Computer Simulation, Decision Support Techniques, Female, Fractures, Bone, Humans, Male, Risk, Risk Assessment, Risk Factors

Denna post skapades 2010-01-08. Senast ändrad 2010-01-26.
CPL Pubid: 105984


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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)



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