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2,6,8-Trisubstituted 3-hydroxychromone derivatives as fluorophores for live-cell imaging.

Christine Dyrager ; Annika Friberg ; Kristian Dahlén ; Maria Fridén-Saxin ; Karl Börjesson (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Marcus Wilhelmsson (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Maria Smedh ; Morten Grøtli ; Kristina Luthman
Chemistry (Weinheim an der Bergstrasse, Germany) (1521-3765). Vol. 15 (2009), 37, p. 9417-23.
[Artikel, refereegranskad vetenskaplig]

We present the synthesis and photophysical characterisation of a series of structurally diverse, fluorescent 2,6,8-trisubstituted 3-hydroxychromone derivatives with high fluorescence quantum yields and molar extinction coefficients. Two of these derivatives (9 and 10 a) have been studied as fluorophores for cellular imaging in HeLa cells and show excellent permeability and promising fluorescence properties in a cellular environment. In addition, we have demonstrated by photophysical characterisation of 3-isobutyroxychromone derivatives that esterification of the 3-hydroxyl group results in acceptable and useful fluorescence properties.



Denna post skapades 2009-10-23. Senast ändrad 2015-08-25.
CPL Pubid: 100642

 

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Institutioner (Chalmers)

Institutionen för kemi (2001-2011)
Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)
Institutionen för fysik (GU) (GU)

Ämnesområden

Kemi

Chalmers infrastruktur