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Kinetics of the formation of cancer metastases via induced premetastatic cancer-stem-cell niches

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Physical Review E. Statistical, Nonlinear, and Soft Matter Physics (1539-3755). Vol. 79 (2009), p. 061913.
[Artikel, refereegranskad vetenskaplig]

The author presents a kinetic model describing the formation of new metastases by cancer stem cells in premetastatic stem-cell niches induced by the factors produced by a primary tumor and already formed metastases. The corresponding kinetics is analyzed by employing mean-field kinetic equations and Monte Carlo simulations. In agreement with observations, the model predicts a long latent period with low rate of the metastase growth followed by explosive increase in the number of metastases. The duration of the latent period is found to depend on a multitude of rate constants characterizing various processes.



Denna post skapades 2009-10-13. Senast ändrad 2013-05-06.
CPL Pubid: 100085

 

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Institutioner (Chalmers)

Institutionen för teknisk fysik, Kemisk fysik (1900-2015)

Ämnesområden

Kemisk fysik

Chalmers infrastruktur