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Oscillatory kinetics of gene expression: Protein conversion and slow mRNA transport

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Journal of Experimental and Theoretical Physics (1063-7761). Vol. 108 (2009), 6, p. 1050-1053.
[Artikel, refereegranskad vetenskaplig]

The negative feedback between mRNA and regulatory-protein production may result in oscillations in the kinetics of gene expression if the mRNA-protein interplay includes protein conversion. Using a mean-field kinetic model, we show that such oscillations can be amplified due to limitations of the mRNA transport between the nucleus and cytoplasm. This effect may be dramatic for the mRNA population in the nucleus.



Denna post skapades 2009-10-13. Senast ändrad 2013-10-29.
CPL Pubid: 100084

 

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Institutioner (Chalmers)

Institutionen för teknisk fysik, Kemisk fysik (1900-2015)

Ämnesområden

Kemisk fysik

Chalmers infrastruktur