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Signal propagation in stem-cell niches

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Physica A - Statistical mechanics and its applications (0378-4371). Vol. 388 (2009), 18, p. 3791-3797.
[Artikel, refereegranskad vetenskaplig]

Stem cells, maintaining tissue homeostasis, are nurtured in microscopic niches formed of so-called environmental cells. The kinetics of proliferation and differentiation of stem cells in such niches depend on their interaction with the messenger proteins secreted by environmental cells. We propose a generic mean-field kinetic model of the propagation of such signals. To motivate our study, we briefly describe a stem-cell niche in the Drosophila ovary. Our model is however applicable to other niches as well. In particular, it helps one to understand the necessary conditions for the niche function. For example, the model predicts that in the case of the Drosophila ovary each germline stem cell should have in the external membrane at least 700 receptors interacting with the signaling Dpp and Gpp proteins emanating from the cap cells.

Nyckelord: Stem-cell proliferation and differentiation; Environmental cells; Signaling proteins; Protein diffusion; Protein degradation; Receptors; Drosophila ovary; Reaction-diffusion kinetic equations

Denna post skapades 2009-10-13. Senast ändrad 2013-10-29.
CPL Pubid: 100082


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Institutioner (Chalmers)

Institutionen för teknisk fysik, Kemisk fysik (1900-2015)


Kemisk fysik

Chalmers infrastruktur